Title: Prognostic features of renal sarcomas
Hakan Ozturk is a faculty in Department of Urology, School of Medicine, Sifa University, Turkey
The aim of the present study was to evaluate the prognostic features of primary sarcomas of the kidney.
Material and Methods:
A literature review was conducted in various databases, including Medline (PubMed) and Scorpus for articles published between January 1992 and December 2013. Among the articles published in English, those describing prognostic features in primary sarcomas of the kidney were recorded. The electronic search was limited to the following keywords: sarcoma, renal sarcoma, prognosis, diagnosis, immunohistochemistry, genetic, and survey. There were no review articles and/or meta-analyses related to the prognosis of primary sarcoma of the kidney. A total of 31 articles related to case reports, case series, and overall prognosis of urological soft tissue sarcomas were reviewed.
Results: Primary sarcoma of the kidney has a poor prognosis compared to other sarcomas of the urogenital system. Other than surgical excision of the renal sarcomas, pathological, molecular, and genetic prognostic factors are also considered to exist. There are no studies randomizing the prognostic features due to the small number of cases. The elucidation of the so-called "chaotic" genetic and molecular basis of the tumor will help to predict the prognosis. Conclusion: Surgical excision is the most significant parameter determining the prognosis in the sarcomas of the kidney. However, sarcomas have prognostic features based on their pathological, genetic, and molecular basis. The current study suggests that other factors could also be important in predicting the prognosis, and clinicians should plan treatment and follow-up according to these factors.