Ain Shams University, Egypt
Title: Role of bone morphogenetic protein-2 in primary Knee osteoarthritis
Abeer Ahmed Kadry El-Zoheiry is a Ass. Professor of physical medicine, rheumatology and rehabilitation, Ain shams university hospitals. She did her M.D. degree in physical medicine, rheumatology and rehabilitation, in Nov 2007 in Ain shams university. She has Unrestricted license to practice medicine in Egypt 138689, active member of the Egyptian society of Rheumatology and Rehabilitation, Egyptian society of joint disorders and arthritis, American Association of Neuromuscular & Electrodiagnostic medicine( AANEM).
Introduction: Many different factors contribute to the onset and progression of OA. The bone morphogenetic proteins (BMPs), that are subsets of the (TGF- B) superfamily, stimulate production of extracellular matrix components by chondrocytes and have the ability to counteract catabolic cytokines like interleukin 1 (IL-1). Aim of the work: The aim of this study was to investigate the role of plasma BMP-2 in primary knee osteoarthritis and its relation to disease severity. Methodology: The study included 30 patients with primary knee O.A and ten apparently healthy matched individuals as a control group. Plasma levels of BMP-2, radiological severity of the disease, pain intensity as well as, assessment of functional status using the Western Ontario and Mc Master University Osteoarthritis Index (WOMAC) were done. Results: Plasma levels of BMP-2 were significantly higher in patients than in control group. Patients with palpable osteophytes have the highest BMP-2 levels. A strong positive correlation was found between plasma levels of BMP-2 and each of: radiological severity, disease duration and WOMAC score. In conclusion :BMP-2 levels correlate with radiographic severity of O.A. which make such biomarker measurement may not only act as a substitute marker for the disease, but also has the potential to contribute to the fundamental processes underlying the pathogenesis of O.A.
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