OmniActive Health Technologies Inc. Morristown, USA
Title: Soluble lutein (lutemax2020®) prevents retinal damage in streptozotocin (stz)-induced diabetic rats
Juturu has a doctoral degree in Clinical Nutrition (Cardiovascular Nutrition) from S.V. University in India (1996) and completed her postdoctoral research in Cardiovascular Nutrition at Penn State University (1997-2000). Dr. Juturu is working as a Manager, Scientific and Clinical Affairs at Omni Active Health Technologies, Inc. She worked in research and development to consumer companies for more than fifteen years. She is an adjunct faculty to teach nutrition courses, NY. She has published research papers in reputed journals, text books, monographs and CEs. She is a reviewer and editorial board member of several national and international journals. She has received awards from Indian Council of Medical Research, Indian Society of Atherosclerosis Research, Cardiology Society of India, American College of Nutrition, Academy of Nutrition and Dietetics and Tinsley Harrison Award from Southern Society of Clinical Investigators. She was honored as honorable speaker, session chair and working committee member for Professional societies such as American Diabetes Association, Academy of Nutrition and Dietetics and American College of Nutrition.
The aim of the present study was to investigate the protective effects of Lutein in streptozotocin-induced (STZ) diabetic rat retina. Male Wistar rats were divided into four groups [Group I, Control (standard diet); Group II, DM; Group III: Group II + regular lutein [RL, lutein 0.5 %]and Group IV [Group II +soluble lutein [SL,Lutemax2020® 0.5 %]. All the animals were housed in individual cages maintained on their respective diets for 12 weeks and drinking water was provided ad libitum throughout the study period. DM was induced in overnight fasted animals by a single intraperitoneal injection of STZ (30 mg/ kg) in 0.1 M citrate buffer, pH 4.5.SL significantly prevented reduction in total retinal thickness better than that of RL as evidenced by H & E stainingqRT PCR, western blot and immunohistochemistry studies showed lowered expression of VEGF and PDGF (stimulates vasculogenesis and angiogenesis in the retina) in group-SL when compared to group-D. SL prevented loss of rhodopsin and nerve growth factor proteins as assessed by qRT PCR and immunofluorescence. Increased expression of stress proteins like glialfibrillary acidic protein (GFAP) and hypoxia-inducible factor 1-alpha (HIF-1A) is prevented by the SL more effectively than the RL. These results demonstrate that lutein has great potential in preventing diabetes-induced retinal degeneration.
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