Northwestern University School of Medicine, USA
Title: Studies of nanoparticle targeting in cancer cells
Dr. Gayle Woloschak is currently a professor of Radiation Oncology at Northwestern University in Chicago and an adjunct professor of Religion and Science at Lutheran School of Theology Chicago, and at Pittsburgh Theological Seminary. She holds a Ph.D. in Biomedical Sciences from the University of Toledo (Medical College of Ohio), and a D.Min. in Eastern Christian Studies from Pittsburgh Theological Seminary. Her laboratory interests include molecular biology, radiation biology and nano-biotechnology, and her science-religion fields include biological evolution, stem cell reasearch, and ecology.
TiO2 nanoparticles can be used for both imaging and treatment of cancer: (1) a variety of different molecules can be placed on the surface of the nanoparticle for therapy, targeting, or imaging and (2) TiO2 itself can be activated with radiant energies higher than the band gap generating the release of OH. radicals that can damage DNA and other biomolecules. We have explored the uptake of TiO2 nanoparticles through a variety of endocytic pathways and have also explored cellular and intracellular targeting of the nanoparticles with ligands that bind to surface receptors, nuclear proteins, and others. A variety of approaches were used to image the nanoparticles including the use of the newly developed bionanoprobe at the Advanced Photon Source at Argonne National Laboratory.