Nationwide Children's Hospital, USA
Title: The DNABII family of proteins: Diagnostic markers and therapeutic targets of bacterial biofilms
Dr. Goodman is a principal investigator in the Center for Microbial Pathogenesis. His research focuses on gene regulation in biofilms, bacterial surface detection and attachment, horizontal gene transfer (HGT) and metagenomics, and bacterial histones. 1. Gene Regulation in Biofilms: In nature, bacteria are often found in complex microbial ecosystems. In some cases these bacteria associate to form interactive systems commonly referred to as biofilms. The oral cavity is home to hundreds of bacteria. One of these bacteria, Streptococcus mutans, causes dental caries (cavities) and is known to form biofilms (plaque) on the surface of teeth.