Taif University, Kingdom of Saudi Arabia
Title: To compare serum leptin levels in obese women with polycystic ovary syndrome (PCOS) and normal ovulatory obese subjects in Saudi Arabia, and to evaluate the interrelationship between leptin concentration, sex hormones, and insulin resistance.
Dr.Nisreen Aref has completed her M.B.B.S from Dammam university She had Arab Board & Jordanian Board for OB.GYN Specialization in 1996 & 1998 respectively. She had subspecialty training certificate in assisted reproductive technology from Kinf Faisal Specialist Hospital & Research Center/Jeddah. She got European Universities Diploma in Gynecological Operative Surgery from France on 2006. She is having Post Graduate Diploma in TQM in health care as well as Diploma in Hospital &Healthcare Management from American university in CAIRO in 2011 & 2013 respectively. Currently she is the Chief of Obstetrics & Gynecology Department in Faculty of Medicine of Taif University / Saudi Arabia
The present study was conducted on 40 women with PCOS (34.3 ± 2.08 years, body mass index (BMI) 34.84 ± 4.77 kg/m2, mean +/- SD) and 16 obese women as control group (28.1 ± 4.61 years, BMI 33.59 ± 1.23 kg/m2). Diagnostic criteria for PCOS based on the presence of two out of three traits including oligo –and/or anovulation, clinical and/or biochemical signs of hyperandrogenism and the presence of polycystic ovaries on ultrasound scan. Concentrations of testosterone, progesterone, prolactin, gonadotrophins, glucose, insulin, and leptin were measured in the baseline fasting blood sample. Serum leptin concentrations were measured by enzyme linked immunosorbant assay. Serum leptin levels in PCOS patients were significantly higher than in the control group (p= 0.005) independently of BMI, and were significantly different between insulin resistant and non-insulin resistant obese PCOS (p= 0.044), In PCOS patients there was a positive correlation between leptin and BMI (p=0.049), and there was no correlation between leptin and other hormonal indices in PCOS patients.