University of Pennsylvania, USA
Title: Using nascent RNAs to study the transcriptional regulation in adipocytes
Kyoung-Jae Won has completed his Ph.D. University of Southampton, UK in 2006 and postdoctoral studies from University of Copenhagen, Denmark and University of California, San Diego. He is a research assistant professor of Genetics at the University of Pennsylvania. He has published more than 20 papers in reputed journals.
Rosiglitazone (rosi) is an insulin sensitizing drug that functions as a ligand for PPAR and remodels the transcriptome of mature adipocytes. However, the direct effects of rosi on genomic transcription have not been evaluated. Here, using global run-on followed by deep sequencing (GRO-seq), we demonstrate that rosi has dramatic effects on RNA transcription in mature adipocytes.
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