Tamil Nadu Veterinary and Animal Sciences University
Title: Veterinary pharmacovigilance survey conducted in Tamil Nadu state, India – A status report
Sarathchandra Ghadevaru is the Professor & Head, Pharmacovigilance Laboratory for Animal Feed and Food Safety in the Directorate of Centre for Animal Health Studies, Tamil Nadu Veterinary and Animal Sciences University, Chennai-51. He is a Veterinary Pharmacology and Toxicologist having 25 years of experience in the field of Veterinary Pharmacology and Toxicology. He obtained Ph.D., (Environmental Toxicology), University of Madras in 1997. His area of specialization is Veterinary Diagnostic and Regulatory Toxicology. His doctoral programme elicited the toxicodynamics/ mode of action and antidotes to combat one of the common suicidal and homicidal phytotoxin (Cleistanthus collinus (oduvan thalai: Tamil) very frequently encountered in malicious poisoning of cattle. The growing resonance in reduction of animals for toxicity evaluation (alternatives to animal toxicity testing), the findings of the phytotoxin were evaluated in two invitro system namely vero cell line and chick embryo as suitable model for alternative to animal toxicity. His mission is to create awareness to livestock farmer regarding residue free livestock products towards Global Food Security
Veterinary pharmacovigilance monitors the safety of veterinary medicines, including vaccines (VAC) used for the prophylaxis, diagnosis or treatment of diseases in animals once they reach the market after authorization. In India, there is no present government policy to survey and evaluate adverse drug events (ADEs) / Pharmacovigilance programme for veterinary medicines. Therefore, essential information such as frequency, severity of treated animal ADEs and reliable data about frequent ADE-producing drugs remains unknown. The objective of the study was to assess and communicate risks and benefits in the market ultimately to educate the veterinarians and the stake holders on the safety and efficacy of veterinary drugs and biologicals. A 12-month period pilot study was conducted to monitor the ADE for frequently used drugs (labeled/extra labeled drugs). A survey protocol consisting of a questionnaire about used drugs in livestock was developed; the questionnaire was distributed to 300 veterinarians of Tamil Nadu state. The veterinarians were instructed to voluntarily report on the various types of drugs used and the ADEs, if any observed. More than 37% ADEs were related to antimicrobials, antiparasitic and anti-inflammatory agents. A further 27% of ADEs were due to vitamins and feed additives. Two cases of ADEs were observed in FMD vaccination, in cattle and canine Parvo vaccine in dogs. In poultry, tiamulin and salinomycin ADEs induced serious mortality. The present study warrants for the need of sustained veterinary pharmacovigilance programmes in livestock for timely ADEs presenting drug detections and drug safety improvement.
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