Abstracts from Cardiovascular Pharmacology: Open Access

An Approach for ECG Feature Extraction and Classification of Cardiac Abnormalities

This inquires about article presents a unused approach to the Programmed location and classification of electrocardiogram (ECG) signals is of tremendous significance for determination of cardiac anomalies. A strategy is proposed here to classify distinctive cardiac variations from the norm like Ventricular Arrythmias, Myocardial.. Read More

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CYP-450 Epoxygenase Derived Epoxyeicosatrienoic Acid Contribute To Reversal of Heart Failure in Obesity-Induced Diabetic Cardiomyopathy via PGC-1α Activation

We have previously shown that an Epoxyeicosatrienoic Acid (EET) -agonist has pleiotropic effects and reverses cardiomyopathy by decreasing inflammatory molecules and increasing antioxidant signaling. We hypothesized that administration of an EET agonist would increase Peroxisome proliferator-activated receptor-gamma coactivator .. Read More

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New Insights in to Molecular Therapeutic Mechanism of Statin Action in Heart Failure: Use of High-Throughput Transcriptome Analysis

Background and objective: The etiology of heart failure (HF) is multifactorial and a variety of mediators are involved in its progression. Thus, elucidation of transcriptome complexity and understanding the functions of differentially expressed genes, together with therapeutic molecular mechanisms underlying development of HF, a.. Read More

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Anti-Thrombotic Drug Problems

Antithrombotic therapy is associated with significant medical complications, particularly bleeding of the anticoagulants used long term by the oral route, warfarin is the safest because the dosage is regularly adjusted according to the results of INR tests. There have recently come into common use a number of oral anti-coagulant.. Read More

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FPU Recurrence in the Coupled Blood Pressure Dynamics in Magisterial and Small Arteries Networks and the Character of its Interaction with the Heart Electrical Activity

Computer model simulating the coupled blood pressure dynamics in magisterial and small arteries with the heart electrical dynamics has been suggested. The Fermi-Pasta-Ulam auto recurrence in the description of the electrical activity of the heart has demonstrated the universal role of the FPU recurrence in the study of dynamical.. Read More

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Impervious Coronary No-Reflow: A Case Study

Coronary no-reflow phenomenon is a disorder of the microvasculature that results in poor myocardial perfusion in patients with acute myocardial infarction receiving percutaneous coronary intervention. It typically manifests as TIMI 1-2 flow, high TIMI frame counts, and abnormal myocardial blush. The etiology of this condition is.. Read More

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A Deep Prospective of Complications in Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

In high-cholesterol countries such as Western Europe and USA, hypertension, through numerous epidemiological studies, has been established as a definite and, risk factor for the development of coronary heart disease (CHD). This is in contrast to the epidemiological situation in certain Eastern countries... Read More

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Atherosclerosis and Metabolic Syndrome-significance of Inflammation, Urgency of Weight Loss and Extracorporeal Removal of Proinflammatory and Proatherogenic Substances

The link between atherosclerosis and metabolic syndrome is through system inflammation. Molecular mechanisms of this link can be explained by hypothesis that arterial hypertension, central obesity and insulin resistance are connected through dysfunction of endothelium and inflammation, where major role play tumor necrosis factor.. Read More

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Penicillin use and its Impact for the Secondary Prevention of Rheumatic Fever/Rheumatic Heart Disease in a Tertiary Hospital in South Africa

Introduction: Acute rheumatic fever (ARF) is a post infectious, non-suppurative sequela of pharyngeal infection with streptococcal pyogens, or group a beta haemolytic streptococcus. Rheumatic heart disease (RHD) is a condition of global health importance. It is estimated that 15.6-19.6 million people are living with RHD, with al.. Read More

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Hypertrophic and Inflammatory Markers in Isoproterenol-Induced CardiacHypertrophy and its Pharmacological Correction

Backgrounds: Short-term sustained beta-adrenergic stimulation is a hallmark of sympathetic hyperactivity and a common future in cardiovascular disease. Activation of endogenous cell signaling pathways that negatively regulate cardiac hypertrophy including the decline of NAD and the reduction of the intracellular NAD+/NADH ratio... Read More

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Down Syndrome with Unbalanced Complete Atrioventricular Septal Defect and Truncus Arteriosus

Truncus arteriosus (TA) is a rare cardiac anomaly constituting less than 1% of all congenital heart defects. The association of complete atrioventricular septal defect (AVSD) and truncus arteriosus is uncommon. The management of this uncommon combination of lesions has not been well characterized and there is limited surgical op.. Read More

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Assessing Calcification Onset in Aortic Valve Interstitial Cells

Aortic valve stenosis (AVS) is one of the most common heart valve diseases, and surgical intervention remains the only viable treatment option. Thus, there is a need for novel and innovative treatments. One approach is to study the biological pathogenesis of this disease in hopes of finding new targets for drug therapy. Although.. Read More

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NADPH Oxidase Inhibition in Heart Failure Improved Vascular Function Associated with Changes in the Novel Genes Expression Revealed by Transcriptome Analysis

Vascular endothelium-dependent vasorelaxation is diminished and reduced skeletal muscle blood flow and correlates with the severity of symptoms in heart failure (HF) as a result of the significant elevation of superoxide anion (O2-) production. There are several sources of (O2-) production within vessels, but NADPH oxidase is pr.. Read More

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The Link between Early Biomarker Analysis and the Neurological Outcome in Stroke Patients

Stroke patients have an uncertain prognosis. It has been postulated that biomarkers’ concentrations upon admission could be linked to the neurological outcome. This meta-analysis reviewed the literature and collected data for 65 biomarkers. To increase power of evidence, only biomarkers who were: • Significant in the.. Read More

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Antiarrhythmic Medications for Cardioversion and Maintenance of Sinus Rhythm in Patients with Cardiac Arrhythmias: A Review of the Literature

Introduction: Cardiac arrhythmias, including supraventricular and ventricular tachycardias, portend a higher risk of morbidity and mortality. These arrhythmias also are associated with increased healthcare resource utilization, decreased quality of life, and increased activity impairment. Pharmacologic conversion is a treatment .. Read More

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Potential of Monocyte Count for the Assessment of Cardiovascular Disease

Atherosclerosis is a chronic inflammatory disease proceeding from an imbalance in lipid metabolism and immune responses. Since leukocytes, especially monocytes and monocyte-derived macrophages, play pivotal roles in the progression of atherosclerosis, it is possible that monocyte count is a beneficial marker for predicting Cardi.. Read More

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Acute Myocardial Injury: A Perspective on Lethal Reperfusion Injury

Acute myocardial infarction contributes significantly to mortality in patients with coronary artery disease. Timely reperfusion of an infarct-related artery within a reasonable time-frame after acute coronary occlusion continues to be the most effective intervention in patients to reduce morbidity and mortality. However, restora.. Read More

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Adrenomedullin Stimulates Porcine Sinus Node Automaticity

Adrenomedullin (AM) is a vasodilatory and chronotropic peptide that has cardioprotective properties in settings of ischemia-reperfusion. Specifically, the 52-amino acid peptide hormone has been shown to reduce infarct size and potentially be protective against malignant arrhythmias. AM reduces L-type calcium currents in rabbit v.. Read More

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Possible Benefits of Direct Oral Anticoagulants for the Electrophysiological Substrate Properties of Atrial Fibrillation: Can these New Agents have Antiatrial Fibrillation Actions?

Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia, and is associated with thromboembolic events. Previous studies also have shown a close relationship between AF and heart failure, and heart failure can be one of the most important risk factors for AF. Therefore, heart failure animal models have been estab.. Read More

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Sodium Glucose Transporter 2 (SGLT2) Inhibition does not Protect the Myocardium from Acute Ischemic Reperfusion Injury but Modulates Post- Ischemic Mitochondrial Function

Background: The Sodium Glucose Transporter 2 (SGLT2)-inhibitor, empagliflozin, reduces death from cardiovascular causes. We hypothesized that the mechanism involved direct protection against Ischemia- Reperfusion (IR) injury and improved post-ischemic mitochondrial function. Methods: We examined infarct size (series I) and mito.. Read More

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