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Macrolide Treatment and Personalized Medicine in Japan
Macrolides are known as antibiotics, but also have various actions, including immunomodulatory effects. Recently, they were suggested that effectiveness for acute infectious diseases, such as influenza and pneumococcal pneumonia by inhibited of cytokines and toxins in addition to chronic infectious diseases like mycobacterium an.. Read More
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Cerebrospinal LDH and Serum Pct in Diagnosis of Meningitis
Context: Meningitis means the membranes that cover the brain, spinal cord and the intervening cerebrospinal fluid inflamed. Aims: To assess the diagnostic role of cerebrospinal LDH and serum procalcitonin in meningitis and differentiating Septic from Aseptic meningitis. Settings and design: Cases were divided into septic menin.. Read More
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The order Rodentia is the most widely existing group on Earth and largest group of small mammals, consist of one fourth the total mammalian species of Pakistan. House mouse, Mus musculus is commensal with human, omnivore and scavenger in nature. It is the definitive as well as intermediate host for trematode parasites. During cu.. Read More
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A Survey of Viral-bacterial Co-infection in Respiratory Samples Using Multiplex Real Time-PCR
Influenza and non-Influenza virus related respiratory tract infections are amongst the most common reasons reported for physician visits and hospitalizations, globally. The economic burden associated with these viral infections, within the United States, are upwards of $50 billion annually. Concomitant, or subsequent, co-infecti.. Read More
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Hydatidosis of the Pelvis: Six Cases and Review of the Literature
Bone hydatid disease is a rare, even in endemic areas like Morocco. There are no parallels between the often poor clinical and extensive anatomical lesions, thus explaining the delay in diagnosis. Our retrospective study of 6 cases of hydatid disease of the collected basin traumatology-orthopedic department at Ibn SINA hospital .. Read More
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Objectives: S. aureus bacteremia (SAB) is a leading cause of infection in patients with chronic kidney disease (CKD). Clinical outcomes associated with SAB in patients with CKD and with non-CKD were compared. Materials and methods: Laboratory and clinical data from patients who were hospitalized with SAB in a tertiary care hosp.. Read More
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A Pilot Study of Nemonoxacin in Patients with Diabetic Foot Infections
Background: Diabetic foot infections (DFIs) are usually caused by a mixture of bacterial pathogens, especially staphylococci (including methicillin-resistant strains). Nemonoxacin, a broad-spectrum non-fluorinated quinolone with activity against methicillin-resistant Staphylococcus aureus (MRSA), could potentially be an effectiv.. Read More
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Aim: Staphylococcus epidermidis is a significant coagulase-negative staphylococci obtained from blood culture samples. However, there is limited information about phenol-soluble modulin (PSM), which is associated with virulence in S. epidermidis and its genetic relatedness in Nigeria. This study observed the presence of phenolso.. Read More
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Invasive Acremonium Infection with Gastrointestinal Dissemination: A Case Report
Acremonium is rare fungal specie that causes mycetoma, mycotic keratitis and onychomycosis, and it may cause disseminated infection in immunocompromised patients. Herein, we report a 17-year-old immuno competent male diagnosed with invasive gastrointestinal acremonium infection. He presented to us with fever and abdominal pain w.. Read More
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Omics Technologies: A Hope for Translational Research in Bovine Tuberculosis
Bovine tuberculosis diagnosis is one of the main challenges faced by animal and public health systems. The incidence of M. bovis infections remains undefined in developed countries. So it is necessary to carry out an extensive study and surveillance to determine the status of bovine tuberculosis as an urgent need for control era.. Read More
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Background: Anemia is an almost constant complication of advanced renal failure, which may worsen preexisting heart disease and as a consequence accelerate the progression of renal dysfunction. Patients with hepatitis C virus (HCV) infection are associated with higher hemoglobin and hematocrit values compared with those with no .. Read More
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Background: Hepatitis C Virus (HCV) has complex interactions with human lipid metabolism leading to down regulation of cholesterol level. Interferon (IFN) therapy has been shown to decrease cholesterol even further during treatment but increase after successful HCV eradication. With the availability of second-generation direct a.. Read More
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Hydatid Cyst of Limb Soft Tissues (11 Cases)
Purpose of the study: Hydatidosis is a parasitic disease caused by the larval form of tapeworm Echinococcus granulosis. Diagnosis is based on interview, clinic and imaging data. This study aims to identify the clinical, paraclinical, therapeutic and evolutionary features of hydatid cyst of the soft tissues in the limbs. M.. Read More
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Background: Treatment regimens for chronic hepatitis B virus (HBV) infection are efficient in suppressing viral load and improving hepatocellular injury and its complications. However, current antiviral agents such as nucleos(t)ide analogues or interferon-alpha are inefficient to reconstitute immunologic control of a persistent .. Read More
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Are PCV2-Cattle Infections at an Early Evolutionary Virus Adaption Stage?
Porcine circovirus type 2 (PCV2) has a major economic impact on pig production. Vaccination against the virus appears to keep PCV2 disease (PCVD) manifestations in check. Nevertheless, PCV2 has not been eliminated. Several reports indicate that cattle also seem to be susceptible to PCV2 infection. In this study, we detected incr.. Read More
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An Ultra-rare Hereditary Disease of 28–year Old Pregnant Patient withMalignant Alteration
Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized by the development of hundreds to thousands of colorectal adenomatous polyps and the inevitable occurrence of colorectal carcinoma, if the colon is not removed. In a 28-year old patient, following diagnostic criteria, have been established more .. Read More
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Update on Enterovirus 71 Infections: Epidemiology, Molecular Epidemiology, and Vaccine Development
Enterovirus 71 (EV71) infections are one of the main etiological agents of hand, foot and mouth disease (HFMD), or herpangina, worldwide. The purpose of this study was to explore the epidemiology and molecular epidemiology of EV71 infection as well as the prospects for the development of an EV71 vaccine. We performed a search fo.. Read More
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Tuberculous Spondylitis. Burden of Diagnosis. Case Presentation
Introduction: Tuberculosis continues to pose a problem of public health worldwide. Mycobacterium tuberculosis infects 1/3 of the world's population and seems to be responsible for 1.4 million deaths annually. In our country, the incidence is 6.5 times higher than in the EU countries. In 2016 there were 12836 cases of pulmonary T.. Read More
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Compared to the early stage (2011-2012) after the Great East Japan Earthquake, no significant changes were seen in the total number of case of tuberculosis (TB), and pulmonary TB cases in the mid-term stage (2013-2014). However, the number of patients with latent tuberculosis infection (LTBI) decreased significantly in the coast.. Read More
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Extensively Drug-Resistant Tuberculosis in India: Prevalence, Incidence and Burden
Extensively Drug-Resistant Tuberculosis (XDR-TB) is a recent challenge for tuberculosis control program. The absence of the functional drugs and high rate of the failure in treatment and mortality rate also high jeopardize for epidemiology. Its prevalence is unknown in India as there was no nationwide counselling. Globally, ther.. Read More
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