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Aim: Physiologically Based Pharmacokinetic (PBPK) model is developed to (1) simulate clinical trials involving the Drug-Drug Interactions (DDI) between fluconazole and drugs (substrates) metabolized primarily by CYP2C9 and CYP3A, and to (2) support dosing recommendations. Methods: The plasma-concentration profiles were simulate.. Read More
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With the advent of deadly SARS-CoV-2, public health organizations and researchers emphasized the timely detection and identification of the virus to limit the spread. Different tests were designed to detect coronaviruses for timely and rapid identification, including Polymerase Chain Reaction (PCR) that detects the organism's ge.. Read More
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Lower Respiratory Tract Infection due to Lophomonas blattarum: A Report of Two Cases and a Review
Here, we describe two cases of Lophomonas blattarum bronchopulmonary infection. The first patient was diagnosed for long years with chronic lymphocytic leukemia and was stable all through his course. The second patient was an immunocompetent patient. Both patients presented within a month for admission with a non-resolving lower.. Read More
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Introduction: Some women are experiencing menstrual changes, including altered menstrual duration, volume (heavier bleeding), increased dysmenorrhea, and worsened Premenstrual Syndrome (PMS) following Coronavirus disease 2019 (COVID-19) spike vaccinations. Appreciation of these as temporal adverse events associated with COVID-19.. Read More
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Background: Recent reports of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) have raised concerns about fungal super-infections in critically ill patients with COVID-19. However, true incidence of CAPA is difficult to estimate given the challenges of diagnosing invasive pulmonary aspergillosis as w.. Read More
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Background: Studies evaluating the effectiveness of ivermectin in reducing time to recovery in patients with COVID-19 have yielded mixed results. We conducted a systematic review and meta-analysis to determine if ivermectin was effective in patients with COVID-19. Methods: Six databases were searched for Randomised Controlled T.. Read More
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019 in Wuhan, China. Due to its hasty dissemination, the novel coronavirus has infected over 500 million people worldwide. Given that pregnancy is an immunocompromised state, pregnant patients have larger risk of contract SARS-CoV-2 compared with non-p.. Read More
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Objectives: In the context of the SARS-CoV-2 pandemic, it is important to better understand whether and, more importantly, how long individuals who were administered a SARS-CoV-2 vaccination are protected from future infections. Healthcare workers are at permanent risk of exposure to SARS-CoV-2-safe and lasting vaccination respo.. Read More
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Brevibacillus texasporus peptide (BT peptide) is immunomodulatory in poultry as a feed additive to substitute antibiotics. In the present study we performed 16S rRNA gene sequencing to compare development of the cecal microbial communities in Clostridium Perfringens-challenged broilers fed basal diet only or with either BT pepti.. Read More
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Prophylactic vaccination and early detection of cervical cancers can effectively prevent Human Papilloma Virus (HPV) infection. HPV major capsid protein (HPV L1), a coat protein assembles into Virus-Like Particles (VLPs), acts as a potent immunogen. In the present investigational study, we evaluated the role of the combination e.. Read More
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Early and rapid detection remains vital to slow the community spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) is currently the diagnostic reference standard for the diagnosis of COVID-19. However, expensive and specialized laboratory instr.. Read More
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Coronavirus disease 2019 (COVID-19) presents as the main cause of death, respiratory and heart failures, especially in the elderly, immunosuppressed, and those with cardiovascular comorbidities. Therefore, a better understanding of these findings is needed. A systematic review was carried out looking for articles published on th.. Read More
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Purpose: The objective of this work is to make an observational study of the usage in moderate or severe state COVID-19 patients of a new therapeutic commercial product obtained after immunization of horses: CoviFab® ELEA F(ab')2 fragmented equine immunoglobulins anti SARS-CoV2. Methods: Participant centers depend on the P.. Read More
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Background: Ever since the appearance of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease (COVID-19) in Wuhan in mid-December 2019, its spread has been dramatic worldwide. It became apparent that the number of pediatric COVID-19 patients was much lower than in adults. Variable clinical presentations .. Read More
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Objectives: The country Nepal was badly hit in second phase of epidemic due to highly transmitted Delta and Delta plus variant. The aim of this study was to investigate the different characteristics of chest HRCT, X-Ray and abnormalities in laboratory parameters of COVID-19 patients during second phase of epidemic. Methods: COV.. Read More
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Background: To assess the comprehensive dynamics of outcomes during the SARS-CoV-2 B.1.617.2 (Delta variant) compared to the Alpha variant outbreak in the United Kingdom. Methods: In this observational study of the cases reported by Public Health England for confirmed (sequencing and genotyping), SARS-CoV-2 cases Delta variant .. Read More
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Summaries, Analysis and Simulations of COVID-19 Epidemics in Shanghai
Background: Globally COVID-19 epidemics have caused tremendous disasters. As the best city to prevent the COVID-19 infection in China, Shanghai experienced five wave COVID-19 epidemics but only has 388 confirmed cases and 7 deaths from January 20 2020 to January 4, 2022. Methods: This study summarizes, analyzes and simulates CO.. Read More
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Infection Prevention Measures in Oral Health Care in Japan
It is important to carry out oral care in compliance with standard procedures. The sterility of the instruments and equipment’s are necessary that are being used. Particular attention should be paid for disinfecting methods. It is also necessary to follow preventive measures to avoid further infection for nearby sites. Pat.. Read More
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SARS-CoV-2 as a Trigger in the Development of Tourette’s Like Symptoms
Background: CNS symptoms have been reported in individuals affected by Coronavirus disease 19 (COVID-19). Gut microbiota can affect central physiology via the microbiota-gut-brain axis. We describe Tourette’s-like symptoms resulting from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection disrupting gut .. Read More
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Microbial infections have long been empirically known to be associated with arthritic conditions. Among them, Post-Streptococcal Reactive Arthritis (PSReA), a condition occurring following upper respiratory tract inflammation caused by streptococcal infection, has been reported to be different from Acute Rheumatic Fever (ARF), a.. Read More
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