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The aim of the study is to rapidly produce an energetic SARS-CoV-2 vaccine for an urgent clinical trial. The methods used to conduct the study: (1) a process of serial dilutions in water media and mechanical impacts, as used in homeopathic preparation from viral culture; (2) imprint of electromagnetic field of the virus through.. Read More
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The COVID-19 Pandemic Demonstrates the Need for Robust Governance Responses to Turbulent Problems
The COVID-19 pandemic provides us with a magnifying glass into how the public sector confronts problems that are not only simple or complex, but also turbulent. Turbulent problems demand robust solutions that are flexible, adaptive, and polyvalent enough to realize a particular agenda, function, and value in the face of challeng.. Read More
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Economic and Financial Effects of the 1918-1919 Spanish Flu Pandemic
The 1918-1919 Spanish Flu represented the biggest worldwide health threat prior to the 2020 coronavirus pandemic. Although its mortality effects have been widely studied, much less has been done to assess its economic and financial impact. This mini review incorporates findings from recent studies of the Spanish Flu’s effe.. Read More
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Chlamydia Trachomatis (CT) infection is often mentioned as a silent disease. Reactive Oxygen Species (ROS) can also cause Sperm apoptosis and have negative impact on Sperm parameters. The objectives of this study were to elucidate the association between Sperm parameters and ROS caused by CT infections resulting in male Infertil.. Read More
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Background: Multidrug-resistant Acinetobacter baumannii is an increasing problem worldwide. The objective of this study was to describe the outbreak of Acinetobacter baumannii producing carbapenemases at the Mayotte Hospital Center. Methods: This is a descriptive study using routine data collected prospectively in patients' med.. Read More
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A Rare Localization of Caseating Tuberculous Nodule of Metacarpal: A Case Report
A typical tuberculous infection involving metacarpals and wrist is a very rare representation in both low and high income countries. This was the first case to be investigated in India, where a 57 year old male presented initially with a ganglion cyst affecting the right dorsum of the hand which was symptomless, soft and cystic .. Read More
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To determine clinical differences in features of methicillin-susceptible and resistant Staphylococcus aureus (MSSA and MRSA, respectively) bacteremia, 15 adult patients with MRSA bacteremia were compared with 30 adult patients with MSSA bacteremia who were hospitalized during 2015 – 2018. Compared with MSSA bacteremia pat.. Read More
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The following are two major scientific evidences for PAK1-dependency of coronaviral infection: (i) A tumor suppressor phosphatase called PTEN, which inactivates PAK1, suppresses the coronavirus-induced CCL2- dependent fibrosis of lungs, and (ii) CCL2 expression depends on coronaviral receptor called ACE2 (angiotensin converting .. Read More
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Coronaviruses and the Associated Potential Therapeutics for the Viral Infections
Coronaviruses (CoVs), named after the crown-like spikes on their surfaces, belong to the RNA virus family Coronaviridae. Coronaviruses are enveloped RNA viruses with a linear positive-sense single–stranded genome consisting of the open reading frames (ORFs), the 5’- methylated cap, and the 3’- poly (A) tail. Th.. Read More
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Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (TOF MS) is now widely used to detect pathogens in clinical settings in the world. However, there are some critical points, including polymicrobial samples handling and the kinds of lysis buffer in the protocol of direct identification of specific patho.. Read More
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Epidemiology of Nosocomial Candida Species, Resistance Patterns, and the Associated Crude Mortality
Background: To study the nosocomial Candida epidemiology, susceptibility patterns, and associated cude mortality. Methods: A multicenter prospective study. Laboratory logbooks were reviewed. Candida species considered were isolates or invasive. Patients' records were queried for the characteristics and demography. Statistical a.. Read More
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Background: Acute Respiratory Infection (ARI) is a leading cause of morbidity and mortality worldwide. During a study describing the circulation and the prevalence of respiratory viruses and bacteria in Cambodia, an ancillary analysis focussed on influenza viruses. Method: Between July 2015 and December 2016, 18 to 50-year-old .. Read More
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Outcome of Patients on Second Line of Antiretroviral Therapy in Dakar
Context: In resource-limited countries, late start of antiretroviral treatment, lack of compliance and limited access to viral load testing are all factors that contribute to the increase in the number of second-line patients. Despite this situation, treatment options remain limited in our countries. The objectives of this study.. Read More
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Purpose: The Goal of this study is to describe the aspects socio-demographic, clinical, diagnostic, therapeutic and evolutionary of African human trypanosomiasis (HAT) cases detected in Burkina-Faso from 2005 to 2011 in the context of major migratory phenomena of populations between Burkina Faso and Ivory Coast: A country where .. Read More
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Context: In order to break the chain of tuberculosis transmission, all diagnosed cases must be followed until the treatment is complete. Several factors influence the treatment outcomes, particularly in hospitals where care is provided for patients with the most severe cases. Methodology: The purpose of this retrospective cohor.. Read More
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Background: The present study tried to establish a scoring system to predict the development of disseminated intravascular coagulation (DIC) in obstructive pyelonephritis complicated with upper urinary tract calculi. Methods: We retrospectively reviewed 103 patients who were hospitalized in our institution between 2007 and 2013.. Read More
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Background: As HIV-positive persons survive longer due to the success of combination antiretroviral therapy (ART) in decreasing mortality, the burden of non-communicable diseases including diabetes mellitus (DM) is anticipated to rise. HIV is characterized by systemic inflammations, markers of which decrease quickly following AR.. Read More
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Outbreak of Crimean-Congo Hemorrhagic Fever (CCHF) During Eid-ul- Azha
Crimean-Congo Hemorrhagic Fever (CCHF) is an endemic disease in parts of Africa, Asia, Eastern Europe, and the Middle East. It was first classified in the 1940’s as Crimean Hemorrhagic fever due to an outbreak in Western Crimea in the former USSR. Later in 1969, it was discovered that the causative virus of this disease wa.. Read More
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Estimation of Anti-Tubercular Drug Resistance in Relapse TB Patients in Rims Hospital, Srikakulam
Relapse TB means the patient had a TB he was previously been treated for TB. Most of such patients had Multi-Drug resistance for first line TB treatment. Method and Materials: These studies were conducted based on observational study in this study we utilized quantitative method to find an effected population. Result: we gathere.. Read More
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Background: The use of peripherally inserted central catheter (PICC) lines has steadily grown in hospital settings. We investigated the factors associated with positive blood cultures after PICC line insertion. We also assessed whether pre-PICC blood culture status affects post-insertion blood stream infection (BSI).Methods: A r.. Read More
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