Alzheimerâs disease (AD) is the most common form of dementia,mainly occurring in the aged population (>65 years of age).Pathologically, AD consists of two major hallmarks: neurofibrillarytangles (NFTs) and senile plaques (SPs), which are comprised of hyperphosphorylatedtau (p-tau) filaments and amyloid-β protein (Aβ)fibrils, respectively. Numerous reports suggest that Aβ aggregation,namely the formation of Aβ oligomers, is an early event precedingother pathological changes in AD. Aβ is physiologically generatedfrom the cleavage of amyloid precursor protein by β- and γ-secretasesin the endoplasmic reticulum (ER) and trans-Golgi network or in thelate endosome, then secreted into the extracellular space.
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Last date updated on April, 2024