Osteoarthritis is a heterogeneous and multifactorial disease associated with progressive loss of articular cartilage. The current diagnostic approaches include arthroscopy, radiography and magnetic resonance imaging (MRI). Although arthroscopy is considered the reference standard for evaluating surface alterations of cartilage, it is invasive and of limited value in longitudinal evaluation. Plain film radiography measures cartilage thinning indirectly via âjoint space narrowingâ, and is severely limited by its inability to visualize cartilage directly. MRI provides excellent soft tissue contrast at high spatial resolution, and allows accurate measurement of longitudinal changes in cartilage morphology.
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Last date updated on July, 2014