Manganese-enhanced Magnetic Resonance Imaging (MEMRI) evolved in the late nineties and relies upon the following three main properties of Mn2+: 1) it is a paramagnetic ion and an excellent T1 relaxivity; 2) it is a calcium (Ca2+) analog that can enter excitable cells (voltage-gated calcium receptor and calcium sensing receptor) and, 3) once in the cells Mn2+can be transported along axons by microtubule-dependent axonal transport. To determine the optimal combination of CSF biomarkers, MRI morphometry variable, FDG PET metabolism variables and neuropsychological test scores to differentiate between subjects who are aging normally and those with either MCI or AD
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Last date updated on July, 2014