OMICS International Organises 300+ Conferences Every Year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 500+ Open access journals which contains over 30000 eminent personalities, reputed scientists as editorial board members.
     

Related Conferences

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France

13th International Conference on Neurology and Neurosurgery


June 19-21, 2017 Paris, France
 

Useful Links

Benefits of Publishing
Submit Manuscript
NIH Funded Work

Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a clinically and genetically heterogeneous, late-onset, neurodegenerative disorder of the motor system. Five to ten percent of cases are familial and about 20% of these cases have point mutations in the Cu/Zn superoxide dismutase 1 (SOD-1) gene. Since its discovery, mutations in Cu/Zn superoxide dismutase (SOD-1) have stimulated a huge amount of interest, but the pathogenic mechanisms underlying disease’s induction in familiar cases are still elusive. The most accepted hypothesis is that familiar ALS, SOD-1 positive could be caused by a neuronal damage, due to a gradual accumulation of a toxic product SOD-1 this cumulative damage leads to a disruption of the cytoskeleton and organelle trafficking within motor neuron dendrites. Aggregates do not exclusively occur in neurons, but also in glial cells, raising the question of whether mutant SOD-1 expression in neurons is sufficient per se to induce pyramidal degeneration and sustain disease evolution over time. The familial form is clinically indistinguishable from the sporadic one and to date only few studies have tried to highlight electromyographic differences between sporadic and familiar ALS forms. In Motor Neuron Diseases (MND), standard needle electromyography often reveals evidence of chronic reinnervation (increased motor unit action potential amplitudes and duration, with reduced recruitment), eventually associated with fasciculations and signs of denervation activity in progress, but provides little information about the extent of both motor neuron loss and axonal regeneration.
 
Share this page

Related Journals

Neurosurgery Journals
Bipolar Disorder Journals
Mental Disorders Journal
Autism Journal
Epilepsy Journal
Spine Journal
Spine Research Journal
Stroke Journal
Neuroimmunology Journal
Neurosciences Journal
Multiple Sclerosis Journal
Alzheimers Journal
Depression and Anxiety Journal
Neuroinfectious Diseases Journal
Brain Disorders & Therapy Journal
Neurological Disorders Journal
Neurorehabilitation Journal
 

Subject wise
Open Access Journals

Agri, Food, Aqua & Vet
Chemical Engineering
Dental & Oral Health
Earth & Environmental Sciences
Genetics & Molecular Biology
Immunology & Microbiology
Neurology & Psychiatry
Obesity & Diabetes
Nursing & Health
  Read More»
Meet Inspiring Speakers and Experts at our 1000+ Global Events inclusive of 300+ Conferences, 500+ Workshops and 200+ Symposiums every year on Medical, Pharma, Science, Technology and Business.

Our 2015 Major destinations:
Conferences By Country
   USA    Spain
   Australia   Canada
   UAE   China
   Italy   France
   Germany   India
   UK   Malaysia
   Japan   Singapore
   Brazil   South Africa
  South Korea
 
Conferences By City
Chicago Valencia Beijing
Florida Alicante Houston
Philadelphia Rome San Antonio
Baltimore Birmingham Abu Dhabi
Boston Lexington Las Vegas
Seattle Atlanta Barcelona
New Orleans Brisbane San Francisco
Bengaluru New Delhi Toronto
Dubai London Hyderabad
 
Conferences By Subject
Medical Pharma Veterinary
Agri, Food & Aqua Genetics Molecular Biology
Physics Health care Neuroscience
Chemistry Immunology Nursing
Clinical Massmedia Physics
Environmental Materials Science Microbiology
EEE Environmental  
Chemical Engineering Business & Management
 
Top