alexa An "Old" Approach to the Damage of the Peripheral Nervous System: Do we Still Need Morphology? | OMICS International
ISSN: 2157-7099
Journal of Cytology & Histology

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

An "Old" Approach to the Damage of the Peripheral Nervous System: Do we Still Need Morphology?

Guido Cavaletti* and Paola Marmiroli

Department of Neuroscience and Biomedical Technology, University of Milano-Bicocca, Monza, Via Cadore 48, 20052 Monza (MB), Italy

*Corresponding Author:
Professor Guido Cavaletti
Department of Neuroscience and Biomedical Technology
University of Milano-Bicocca
Monza, Via Cadore 48, 20052 Monza (MB), Italy
Tel: +39-02-6448 8039
Fax: +39 02 6448 8250
E-mail: [email protected]

Received Date: July 17, 2012; Accepted Date: July 18, 2012; Published Date: July 20, 2012

Citation: Cavaletti G, Marmiroli P (2012) An “Old” Approach to the Damage of the Peripheral Nervous System: Do we Still Need Morphology? J Cytol Histol 3:e105. doi:10.4172/2157-7099.1000e105

Copyright: © 2012 Cavaletti G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Cytology & Histology

Research improvement in the field of neuroscience greatly profited from the use of modern techniques based on high-resolution noninvasive imaging, neurophysiological investigation, biomarkers analysis and behavioral assessment. Given the huge amount of sophisticated and highly technological tools available in our laboratories, researchers might find rather obsolete the use of morphological investigation and they can consider training in morphological sciences as a low-return activity. In fact, the observation of biological sample is frequently perceived as an “old”, time consuming, investigator-dependent, highlyvariable approach to experimental neuroscience, hardly able to really capture the normal, physiologic condition that turned to be pathologic in animal models of human diseases. However, this perception is definitely wrong and several examples could be offered in support of the still fundamental importance of the morphological examination of the nervous system and of the need for an extensive training in this technique.

These statements are based on our personal experience as investigators and tutors for young researchers in the PhD program in Neuroscience at our University, where the morphology laboratory is placed at the center of any experimental activity. Although several different examples might be provided to support the fundamental role of the morphological investigation, the study of the peripheral nervous system (where for instance non-invasive imaging is still poorly informative) gives one of the most clear evidence of its relevance and we can give the example provided by the study of chemotherapyinduced peripheral neurotoxicity (CIPN) [1].

CIPN is still a highly-relevant, umnet clinical need since it can be severe, with a remarkable impact on the quality of life of cancer patients and it is a potentially dose limiting side effect of the modern antineoplastic chemotherapy [2]. Its investigation is mandatory since no treatment is currently available to prevent its onset and clinical sign may be long-lasting or even permanent. The peripheral nervous system is a frequent target of the neurotoxicity of several anticancer compounds and the accurate identification of their sites of neurotoxic action has provided valuable clues to understand the pathogenesis and interpreting the clinical features of CIPN.

In fact, while the clinical and neurophysiological features of CIPN may only suggest the possible target of toxicity, morphological studies performed on human specimens (when available) or using reliable animal models can actually demonstrate if a structure is really involved in the pathological process and to what extent. As a further evidence, although the clinical aspects of CIPN induced by different drugs might suggest a common pathogenesis, specific morphological features of neuronal and glial cells damage induced at different levels by platinum compounds, taxanes, vinca alkaloids and bortezomib have been demonstrated, clearly indicating that these drugs act with different mechanisms and on different intracellular targets [3].

These studies have also pointed out that animal models are fundamental in the study of CIPN, since the availability of tissues of human origin is extremely limited. In fact, most of the neurotoxic drugs have some pathologic effect on the dorsal root ganglia neurons, and it is a common experience among morphologists that it is very difficult to obtain high-quality human specimens even from early autopsies.

Supporting the importance of the morphological assessment does not imply that other types of investigation (e.g. neurophysiological and behavioral studies) should be discarded or under-valued in their contribution, but rather than only the complementarity of all the available techniques might really allow a sound scientific development of the modern neuroscience, although the morphological examination still remains the “golden standard” for most studies.

We are therefore convinced that, even in early 21st century, the amount, the quality and the relevance of the information provided by a focused morphological assessment, possibly supported by a morphometric analysis must be considered fundamental research tools and that efforts should be continuous to train our younger fellows in this difficult methodology which tends to be frequently underestimated in its importance.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

Article Usage

  • Total views: 11952
  • [From(publication date):
    August-2012 - Jun 25, 2018]
  • Breakdown by view type
  • HTML page views : 8179
  • PDF downloads : 3773

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

a[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7