Anastomotic leak is a major concern in obese patients because they may experience more intraoperative technical difficulties, comorbidities, and healing delays secondary to neoadjuvant chemoradiation (NCRT). However, the majority of studies included in this review that evaluated this concern in CRC or only rectal cancer did not report any significant differences between obese and non-obese patients. One study showed a higher leak rate in obese patients who did or did not undergo NCRT vs. non-obese patients (14 vs. 5, respectively; p=0.003). But this is related only to mid to lower rectal anastomoses and only 25 of 571 underwent laparoscopy. The authors discussed that the technical complexity expected in obese patients and the low tumor location explain the increased anastomotic leak rate
Review articles are the summary of current state of understanding on a particular research topic. They analyze or discuss research previously published by scientist and academicians rather than reporting novel research results.
Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications.
The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.
Last date updated on September, 2014