|Epidemiological studies and clinical trials indicate conclusively that high serum cholesterol is a major risk factor for coronary heart disease and that lowering cholesterol levels reduces the risk .The three major sizes of lipoprotein particles in which cholesterol circulates in the plasma are: very low density lipoprotein cholesterol (VLDL-C) low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C). Several large epidemiological studies suggest that for each 1 mg.dLâ1 increase in HDL-C, there is an accompanying 2% decrease in coronary heart disease risk in men and a 3% decrease in women. A low LDL-C level does not eliminate the risk impacted by a low HDL-C but a high HDL-C appears to offset some of the risk of a high LDL-C. HDL-C is the âgarbage trucksâ of the blood system, collecting cholesterol and dumping it into the liver. HDL-C plays a critical role in reverse cholesterol transport. It may retard atherogenesis by maintaining endothelial function
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