Pharmaceutical recombinant proteins such as growth hormone, insulin and anti-hemophilic factor VIII were commonly expressed and overproduced in microorganisms such as E. coli. Since the over expression of genes in foreign hosts may form inclusion bodies, further treatments on the secreted proteins are required, including unfolding and refolding processes. Genetic engineering can also be used to increase protein stability. Studying the structural properties and folding processes, Mirzahoseini and Alibolandi investigated the effect of chaperones as heat shock proteins on human basic fibroblast growth factor stability.
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Last date updated on July, 2014