alexa Anticipation of a Novel Gene Therapy Inspired by a Concept of iPS Cells | OMICS International
ISSN : 2153-2435
Pharmaceutica Analytica Acta

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Anticipation of a Novel Gene Therapy Inspired by a Concept of iPS Cells

Fumiaki Uchiumi1,2* and Sei-ichi Tanuma2,3

1Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-shi, Chiba-ken, Japan

2Research Center for RNA Science, RIST, Tokyo University of Science, Noda-shi, Chiba-ken, Japan

3Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-shi, Chiba-ken, Japan

*Corresponding Author:
Fumiaki Uchiumi
Department of Gene Regulation, Faculty of Pharmaceutical Sciences
Tokyo University of Science, Tokyo University of Science
2641 Yamazaki, Noda-shi, Chiba-ken 278-8510, Japan
Tel: +81-4-7121-3616
Fax: +81-4-7121-3608
E-mail: [email protected]

Received date: November 23, 2012; Accepted date: December 17, 2012; Published date: December 21, 2012

Citation: Uchiumi F, Tanuma S (2012) Anticipation of a Novel Gene Therapy Inspired by a Concept of iPS Cells. Pharmaceut Anal Acta 3:196. doi: 10.4172/2153-2435.1000196

Copyright: © 2012 Uchiumi F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Pharmaceutica Analytica Acta

Abstract

This year Nobel Prize in Physiology or Medicine was dedicated to two researches who have established and developed the study in the field of stem cells. At present, there seems to be still several problems to have to overcome before applying the techniques with iPS (induced pluripotent stem) cells to the practical use in the medical treatments. However, the concept of the iPS cells has brought a great hope not only in medicine, especially in regenerative therapies, but also in the development of new drugs. Here, from the point of view of medicine, we propose an another possibility to apply the concept of iPS cells to the new therapy of diseases, such as cancer.

Keywords

Gene therapy; iPS cells; Regenerative therapy; Reprogramming of cells; Transcription factors

The principle of the establishment of iPS cells is based on the cell biology to reprogram a differentiated cell to a state that the cell can differentiate into variety of cell types [1]. Various chemical compounds will be subjected to screening systems to identify or develop drugs that induce cell pluripotency [2]. However, the establishment of the iPS cells was originally demonstrated by the introduction of the set of four gene expression vectors into somatic cells [1,3]. It is frequently referred as Yamanaka factors, comprising of OCT3/4, SOX2, KLF4, and c-MYC. And it should be noted that all the encoded proteins are known as functional transcription factors (TFs) with DNA binding activities [4]. The concept of establishing iPS cells is extremely important to have indicated that only four TFs are required to manipulate cells convert into iPS cells, implying that certain alterations of transcriptional state in a cell can reinforce the cell to go back to its progenitors.

Up to present, a lot of efforts have been taken on the studies of cancer, and it was revealed that many factors, including protooncogene or tumor suppressor gene products and signal transduction proteins, are involved in the generation of tumors [5]. Given that cancer cells are originated from healthy cells, isn’t it possible to reverse the history of cells into healthy state by introducing several TF-encoding gene expression vectors? Sooner or later, comprehensive studies of cancer by genomics or proteomics will indicate right combinations of the TF-encoding genes to regenerate normal cells from cancer cells. If introduction of these TF-encoding genes will make malignant cancer cells to stop growth and to go back into its progenitor like state, the only treatment that physicians need to do for the patients will be to deliver the TF-encoding gene expression vectors into cancer cells. This might be practically possible after the establishment of the genetransfer system that is suitable for each individual cancer cell.

This proposal for the cancer therapy is only an example from the unlimited iPS cell-based concept. All researchers including us, especially who are studying life sciences, had better applaud the establishment of iPS cells that will make impossible to possible.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 11754
  • [From(publication date):
    December-2012 - Jul 22, 2018]
  • Breakdown by view type
  • HTML page views : 7998
  • PDF downloads : 3756
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version