Medicinal Chemistry

A series of sulfonamide derivatives HR1-HR5 were synthesized in one step reaction (nucleophilic substitution reaction SN2). Structures of new products were confirmed by elemental and spectral analysis i.e., FTIR, UV, 1H NMR, 13C NMR, EIS-MS. In-vitro, antibacterial and anti-fungal activity of newly synthesized compounds was investigated against two bacterial strains: Escherichia coli and Staphylococcus aureus and two fungal strains: Aspergillum flavous and Aspergillum niger. It was found that among all tested compounds HR2 showed good antibacterial activity with MIC 1.13 × 10-3 and 1.54 × 10-3 for S. aureus and E. coli respectively. While HR4 showed good antifungal activity with inhibition zone 25.2 ± 0.12 mm (MIC: 71.2 × 10-3 mol/L) and 17.1 ± 55.5 mm (MIC: 98.9 × 10-3 mol/L) against A. flavous and A. niger respectively. Developed compounds were also screened for their Invitro antioxidant activity by DPPH radical scavenging assay. All compounds showed moderate activity but potential activity with 15.75% at 6 mM was exhibited by compound HR2.

In an attempt to design and synthesize a new class of anti-HIV-1 RTIs i.e., 4-(phenyl)-N,N-bis((1-phenyl- 1H-1,2,3-triazol-4-yl)methyl)thiazol-2-amine derivatives, substituted 2-amino-4-phenylthiazoles were alkylated with propargyl bromide to obtain dialkyne 2-amino-4-phenylthiazoles. This dialkyne 2-amino-4-phenylthiazole was reacted with aryl azides to generate small library of 15 compounds (4a-o) by click chemistry. The obtained derivatives were studied for as an anti-HIV-1 NNRT Inhibitors. All synthesized compounds of 1,2,3-triazolylphenylthiazole series were be docked into the non-nucleoside inhibitor binding pocket (NNIBP) of HIV-1 RT and highly inhibiting derivatives studied for in vitro anti-HIV-1 assay.

A series of 1-acyl-4-sulfonylpiperazine derivatives has been prepared. The antiproliferative effect of these compounds was evaluated in vitro against human prostate cancer cell line C4-2, several among them exhibited interesting growth inhibitory against this particular cell line. Finally, a molecular modeling study was employed to analyze the structure/activity relationships (SAR) of these novel compounds..