alexa Acute lymphocytic leukemia | Argentina| PDF | PPT| Case Reports | Symptoms | Treatment

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Acute Lymphocytic Leukemia

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  • Acute lymphocytic leukemia

     Acute lymphoblastic leukemia, also known as acute lymphocytic leukemia or acute lymphoid leukemia (ALL), is an acute form ofleukemia, or cancer of the white blood cells, characterized by the overproduction and accumulation of cancerous, immature white blood cells, known as lymphoblasts.

    Typical symptoms 

    • Generalized weakness and fatigue, Anemia, Dizziness, Weight loss and/or loss of appetite, Excessive and unexplained bruising, Bone pain, joint pain (caused by the spread of "blast" cells to the surface of the bone or into the joint from the marrow cavity), Enlarged lymph nodes, liver and/or spleen, Petechiae, which are tiny red spots or lines in the skin due to low platelet levels.

  • Acute lymphocytic leukemia

    Treatment and Medication

    Chemotherapy, Remission induction, Consolidation, Maintenance therapy, Immunotherapy, Biological therapy, Radiation therapy.

  • Acute lymphocytic leukemia

     Statistics

    A total of 380 newly diagnosed children (including 50 infants and 44 T-ALL) were screened by RT-PCR; the incidence of recurrent rearrangements was: ETV6-RUNX1, 12.9%; TCF3-PBX1, 5.0%; BCR-ABL1, 1.6%; and MLL rearrangements, 10.5%. STIL-TAL1 was detected in 22.7% of T-ALL cases.In B-ALL cases, the pEFS was significantly influenced by the presence of genetic alterations. RT-PCR studies improved patients' stratification and also the overall outcome of children treated in a pediatric hospital from a developing country.

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