Adenoviruses are very common and come in many types. Depending on the virus type, adenoviruses can cause respiratory (breathing) problems that can include cough, fever, and runny nose, headache, sore throat and eye infections. Infection with adenovirus can also rarely lead to more serious problems, such as pneumonia, stomach and bowel problems, and even death. Some people who are infected may have to be hospitalized.
Adenoviral vectors are attractive candidates for transfer of foreign genes for a number of reasons. The adenoviral genome is well characterized and comparatively easy to manipulate. Most adenoviruses cause mild diseases in immunocompetent human adults and by deletion of crucial regions of the viral genome the vectors can be rendered replication-defective, which increases their predictability and reduces unwanted side effects.
Approximately 25, 000 reports to WHO from 1967 to 1976 on isolations of adenovirus 1 to 31 showed an absolute frequency of Ad2, 1, 7, 3, 5, 6, 4, 8, and other species, in decreasing order. The relative frequency was analyzed by the X2 method; only significant deviations (p < 0.05; in many cases p < 0.001) from chance distribution were taken into account.