Definition: Antibiotic-associated colitis is an inflammation of the intestines that sometimes occurs following antibiotic treatment and is caused by toxins produced by the bacterium Clostridium difficile. It is determined as the incidence of antibiotic-associated colitis among users of oral antibiotics or topical clindamycin in a large prepaid health plan. When we take antibiotics, they often kill all the good bacteria in your intestine. This creates a perfect home for bacteria called Clostridium difficile ( C. diff) .
Causes: Antibiotic-associated colitis is caused by toxins produced by the bacterium Clostridium difficile after treatment with antibiotics. When most of the other intestinal bacteria have been killed, Clostridium difficile grows rapidly and releases toxins that damage the intestinal wall. The disease and symptoms are caused by these toxins, not by the bacterium itself.
Symptoms: TThe early signs and symptoms of this disease include lower abdominal cramps, an increased need to pass stool and watery diarrhea, As the disease progresses, the patient may experience a general ill feeling, fatigue, abdominal pain, and fever. If the disease proceeds to pseudomembranous enterocolitis, the patient may also experience nausea, vomiting, large amounts of watery diarrhea, and a very high fever (104-105°F/40-40.5°C).