Hearing loss is a common problem caused by noise, disease, aging, illness, and genetics. General signs of hearing loss occurs suddenly and develops gradually that includes asking people to repeat themselves, listening to music or television with a higher volume than required. There are two main types of hearing loss depending on where the problem lies they are conductive hearing loss, sensorineural hearing loss.
Sensorineural is caused by damage to the auditory nerve that occurs naturally with age. There are several options that help to improve a person’s ability to hear and communicate which includes digital hearing aids, cochlear implants, middle ear implants, bone anchored implants, wireless devices, etc. The 35delG mutation was detected in 11/ 712 unrelated blood donors.
In 7 out of 46 patients (15.2%) only one mutant allele was detected. Of their 38 chromosomes, 71% resulted with mutations in the GJB2 gene and 11% in GJB6. The most frequent mutation in GJB2 (24%) was c.35delG (11% homozygous and 13% heterozygous and compound heterozygous). In addition, 11 sequence variations different from c.35delG, were identified in the coding region of the GJB2 gene: T8M, V27I, M34T, E47X, R75W, W77R, I82M, L90P, E129K, V153I, M163V.