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Hemoglobinopathies

  • Hemoglobinopathies

    Haemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of thehemoglobinmolecule. Hemoglobinopathies are inherited single-gene disorders; in most cases, they are inherited as autosomal co-dominant traits. Common hemoglobinopathies include sickle-cell disease. It is estimated that 7% of world's population (420 million) are carriers, with 60% of total and 70% pathological being in Africa.

  • Hemoglobinopathies

    Haemoglobin Functions :Transport of oxygen from the lungs to the tissues. This is due to the peculiar cooperation of the globin chains that allows the molecule to take in more oxygen where there is increased oxygen and to release oxygen in low concentration of oxygen.Transport of carbondioxide: from the tissue to the lungs.the end product of tissue metabolism is acidic which increases the hydrogen ion in solution. the hydrogen ion combines with bicarbonates to produce.

  • Hemoglobinopathies

    Statistics: The sample consisted of 428 unrelated children between 2 and 15 years of age were analyzed, including a main sample of 397 outpatients randomly recruited at the Pereira Rosell Hospital Centre (CHPR) in 2006 who presented health problems unrelated to hemoglobinopathies. The children were grouped as being of either European (259) or African (138) descent based on their ancestors origin. To be classified as Afro-descendants the children had to have at least one grandparent of African origin.

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