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Marfan syndrome is a connective tissue disorder which causes defects of aorta and heart values. This syndrome might affect eyes, lungs, skeleton, etc. This syndrome is a result of miss folding in glycol protein named fibrillin which is responsible for formation of elastic fibers in connective tissues helps in transforming growth factors. There are many symptoms in people with Marfan syndrome, out of which eyes, aorta, and heart are the most affected.
Diagnosis of this syndrome is based on the family history of major and minor disorders, skeletal signs etc. We identified 2329 patients (58% men) with Marfan syndrome in Argentina. The overall prevalence was 10.2 (95% CI, 9.8-10.7) per 100,000 individuals, with peaks at the age of 15 to 19, 10 to 14, and 20 to 24 years. The minimal birth incidence of 23.3 (95% CI, 21.7-23.3) per 100,000 individuals was estimated in those aged 20 to 29 years.