Non alcoholic fatty liver disease is a term used to describe the accumulation of fat in the liver of people who drink little or no alcohol.At its most severe, non alcoholic fatty liver disease can progress to liver failure. Among 84 circulating miRNAs analysed, miR-122, miR-192, miR-19a and miR-19b, miR-125b, and miR-375 were upregulated >2-fold (p<0.05) either in simple steatosis (SS) or non-alcoholic steatohepatitis (NASH). The most dramatic and significant fold changes were observed in the serum levels of miR-122 (7.2-fold change in NASH vs controls and 3.1-fold change in NASH vs SS) and miR-192 (4.4-fold change in NASH vs controls); these results were replicated in the validation set.
To reduce the risk of nonalcoholic fatty liver disease Choose a healthy diet, Maintain a healthy weight, ExerciseNo standard treatment for non alcoholic fatty liver disease exists.Instead, doctors typically work to treat the risk factors that contribute to the liver disease. For instance, if obese, doctor can help to lose weight through diet, exercise and, in some cases, medications and surgery.