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Pathophysiology
Nerve tumors can form in the peripheral nerve network anywhere in the body. These tumors often affect the function of the nerve, causing pain and disability. A large majority of peripheral nerve tumors are benign. Some are caused by neurofibromatosis, or schwannomatosis. Malignant Peripheral Nerve Sheath Tumors are very aggressive tumors and should be managed by a multi-disciplinary team.
Disease statistics
In Argentina, people newly diagnosed with cancer (excluding NMSC)/yr-115,200; age-standardised rate, incidence per 100,000 people/yr-216.7; risk of getting cancer before age 75-21.8%; people dying from cancer /yr-66,400.
Disease treatment
There are several factors in deciding to surgically remove these tumors. Some, like schwannomas are slow-growing and can be watched using imaging studies over time. Others, like malignant nerve sheath tumors need to be removed immediately, as they are very aggressive.
Major research
Current research in on understanding the molecular mechanisms that normally act to arrest tumor growth as well as those that promote nerve tumor, currently comparing and contrasting the molecular profile of growing and non-growing tumors in patients with NF1.