Disease Property Pathogenesis Gene(s) Onset age Common symptoms Treatment
CADASIL hereditary small cerebral artery disease Aggregation of Notch3 and GOM →degeneration of VSM cells Notch3 on chromosome 19p13 late Ischemic attack, depressive or maniac episodes, migraine, Cognitive and motor impairment Antiepileptic drugs, β blockers, exercise restriction
Marfan syndrome connective tissue disorder Defective connections between smooth muscle cells and elastic fibers FBN1 on chromosome 15q21 variable Loosejoints ,Ectopialentis, myopia β blockers aortic root surgery
Moyamoya disease Cerebral vasculopathic disease Occlusion of supraclinoid internal carotid arteries→arterial collaterals 3p24.2- p26, 6q25, 8q23, 12p12,17q25 childhood Ischemic attack, headache, Intracerebral hemorrhage, motor impairment direct or indirect bypass surgery
HHT Dominant vascular disorder Telangiectasias result in frail blood vessel walls ENG, ACVRL1, MADH4. early Hemorrhage, anemia More iron intake, Surgery to remove the arteriovenous malformations
MOPDII autosomal recessive disease Abnormity in mitotic spindle organization in centrosomes PNCT on 21q22.3 childhood growth retardation, microcephaly hemorrhage, aneurysms hormone therapy
Fabry disease X-linked Lysosome storage disorder lipid accumulation in the lysosome of cells in organs and  vascular endothelium GALA on chromosome Xq22 Late Male earlier than female Stroke, cataracts, painful neuropathy enzyme replacement therapy—α-galactosidase A
Granule and osmiophilic materials (GOM)
Table1: The resumptively listed information of the six neurovascular diseases