| SR.NO |
NAME OF ORGANISM |
DRUG PRODUCED |
MECHANISM OF ACTION |
USE |
JOURNAL NAME |
| 1 |
Streptomyces verticillus[27] |
Bleomycin[26] |
Mediate oxidative degradation of all cellular RNAs[53].
It bind to selective DNA sequence, which is GC rich and destroy DNA[53,54].
Act in G2 phase of cell cycle[54] |
Hodgkin's lymphoma,squamous cell carcinomas,testicular cancer,plantar warts[27] |
Journal of Dermatology[27] |
| 2 |
Streptomyces parvullus[28], |
Dactinomycin[26] |
It inhibit DNA dependent RNA synthesis, by binding to that portion of DNA that is going transcription [55-57] |
testicular cancer and Ewing's sarcoma[28] |
Hand book of oncology[28] |
| 3 |
Streptomyces caespitosusor Streptomyces lavendulae[29] |
Mitomycin[26] |
It bind with thioredoxinreductase enzyme ,present normally in tumors and in activate its active site that contributes its cytotoxicity [58] |
anal cancers, and breast cancers[29] |
J MolecBiol[29] |
| 4 |
Streptomyces galilaeus[30] |
Anthracyline[26] |
Inhibition of topoisomerse 11 enzyme by
Intercalate between adjustant DNA base pairs [59]
Produce hydoroxyl free radicals [59]
|
Solid tumors and hematological malignancies[30] |
American chemical society[30] |
| 6 |
Streptomyces peucetius[31] |
daunomycin and doxorubicin (adriamycin)[26] |
It intercalate into DNA by inhibiting topoisimerase11 enzyme [60]
It produces free radical that damages DNA , RNA and Proteins [60] |
Breast cancer[31] |
Seminar in oncology[31] |
| 7 |
Micromonosporachersina[32] |
Dynemicin A[26]
|
It binds with DNA strand and cleaves it. preferred cleavage site for dyenomicin is 3' side of purine bases [61] |
leukemia, breast and lung cancers[32] |
Chemistry groups[32] |
| 8 |
S. globisporusC-1027[33] |
Lidamycin[26] |
It damages DNA by radicle mediated hydrogen removal |
Myeloma[33] |
Beijing Union Medical College[33] |
