Figure 4: a, b) Altered expression of the MAPK family members. Cells were exposed to F3 or LE (0, 5, 10, and 20 μM) for 48 h then the apoptosis related protein levels of p38, phospho-p38, ERK, phospho-ERK, JNK, phospho-JNK were analyzed by Western blot. c, d) Effects of inhibitor (SB203580) on F3-induced and LE-induced activation of phospho-p38MAPK and p38MAPK. Each experiment was performed in triplicate. *p < 0.05 vs. control (0 μM).