Sl No. Sequences Database Identification No. Role of Indole 1 Boc-Gly-Trp-Ala-OBu TUPGOA Aromatic-Amide Interaction 2 Z-Aib-Trp-Aib-OMe (Two Molecules) ROHVEP Aromatic-Amide Interaction 3 Z-Aib-Aib-Trp-Aib-OMe ROHVIT Aromatic-Aromatic Interaction 4 Boc-Aib-Trp-(Leu-Aib-Ala)2-Phe-Aib-OMe HICKEJ Aromatic-Amide Interaction 5 Gly-Trp-dihydrate GLTRDH01 Aromatic-Aromatic Interaction 6 Ala-Trp monohydrate FUJZUF Aromatic-Aromatic Interaction 7 Trp-Gly monohydrate FULGEY Aromatic-Aromatic Interaction 8 Leu-Trp-Leu.HCldihydrate FUDFUF Aromatic-Aromatic Interaction 9 Trp-Gly-Glydihydrate FIZWOA01 Aromatic-Aromatic Interaction 10 Trp-Gly-Leu GUBDIQ Aromatic-Aromatic Interaction 11 Trp-Met-Asp-Phenylalanylamide GASTRN10 Aromatic-Aromatic Interaction 12 7-methylguanosine-5”-phosphate-Trp-Glu Complex SEKXIP10 Aromatic-Aromatic Interaction

aThe database contained 31 entries with Trp residues. Among them, only acyclic structures with short aromatic - aromatic (centroid - centroid distance between six membered rings of indole ≤ 6.5 Å) and / or aromatic - amide (centroid - centroid distance of five membered ring of indole and amide centroid ≤ 4.5 Å) distances are listed.

Table 1: List of Trp peptides from Cambridge Structural Databasea.