Phenotype Gene ontology terms Pathways obesity phenotypes BP: fat cell differentiation, regulation of lipid metabolic process, triglyceride metabolic process, response to insulin stimulus, regulation of appetite, regulation of response to food, positive regulation of fatty acid oxidation, regulation of cholesterol transport, ovulation PPAR signaling, adipocytokine signaling, mitochondrial uncoupling   MF: interleukin-6 receptor binding     CC: none   BMI BP: positive regulation of fatty acid metabolic process, triglyceride metabolic process, response to insulin stimulus, regulation of fat cell differentiation, regulation of lipid metabolic process, regulation of gluconeogenesis, fatty acid beta-oxidation PPAR signaling, adipocytokine signaling   MF: carnitine O-palmitoyltransferase activity     CC: none   HDL-C BP: reverse cholesterol transport, negative regulation of interleukin-1 beta production, regulation of intestinal cholesterol absorption, regulation of cholesterol storage, triglyceide-rich lipoprotein particle remodeling, HDL particle remodeling, cholesterol homeostasis, triglyceride homeostasis PPAR signaling, chylomicron-mediated lipid transport, CETP-mediated lipid exchange: spherical HDL gains triacylglycerol   MF: phosphatidylcholine-sterol O-acyltransferase activator activity, triglyceride lipase activity     CC: HDL particle, chylomicron, VLDL particle   triglycerides BP: reverse cholesterol transport, lipoprotein metabolic process, triglyceride metabolic process, cholesterol homeostasis, triglyceride homeostasis, lipoprotein particle clearance, response to wounding, HDL particle remodeling, LDL particle remodeling, regulation of cholesterol transport, cholesterol metabolic process PPAR signaling, chylomicron-mediated lipid transport, CETP-mediated lipid exchange: LDL gains cholesterol ester   MF: cholesterol transporter activity, lipoprotein receptor binding     CC: HDL particle, chylomicron, IDL particle, VLDL particle   cholesterol, total BP: triglyceride-rich lipoprotein particle remodeling, HDL particle remodeling, CDC42 protein signal transduction, cholesterol transport, cholesterol homeostasis, triglyceride homeostasis, positive regulation of cholesterol efflux, triglyceride metabolic process, regulation of lipoprotein lipase activity PPAR signaling, chylomicron-mediated lipid transport   MF: HDL receptor binding, LDL receptor binding, cholesterol transporter activity     CC: HDL particle, chylomicron, IDL particle, VLDL particle         Environmental factor physical activity BP: plasma lipoprotein particle remodeling, regulation of inflammatory response, positive regulation of gluconeogenesis, brown fat cell differentiation, blood circulation, vascular process in circulatory system, regulation of blood vessel size, cholesterol homeostasis, regulation of cholesterol transport, reverse cholesterol transport, response to hypoxia, negative regulation of IL1B production PPAR signaling, neuroactive ligand-receptor interaction, adrenoreceptors, chylomicron-mediated lipid transport, CETP-mediated lipid exchange: spherical HDL gains triacylglycerol   MF: cholesterol transporter activity, HDL receptor binding, apolipoprotein receptor binding, beta-adrenergic receptor activity     CC: spherical HDL particle   dietary fat BP: lipid homeostasis, triglyceride homeostasis, reverse cholesterol transport, triglyceride metabolic process, positive regulation of fatty acid metabolic process, negative regulation of macrophage derived foam cell differentiation, cell cycle arrest, VLDL particle remodeling, HDL particle remodeling PPAR signaling, lipoprotein metabolism   MF: triglyceride binding     CC: HDL particle, chylomicron, VLDL particle   dietary saturated fat BP: reverse chlolesterol transport, cholesterol efflux, lipoprotein particle clearance, cholesterol homeostasis, triglyceride homeostasis, regulation of cholesterol transport, regulation of cholesterol storage, negative regulation of macrophage derived foam cell differentiation, triglyceride mobilization, lipid localization PPAR signaling, adipocytokine signaling, chylomicron-mediated lipid transport, CET-mediated lipid exchange: LDL gains cholesterol ester   MF: HDL receptor binding, cholesterol transporter activity     CC: HDL particle, chylomicron, IDL particle, VLDL particle   BP: biological process MF: CC: cellular component

Table 4: Pathway and gene ontology analysis for select phenotypes and envionmental factors showing GxE interactions.