Gene SNP Risk allele Phenotype Environmental factor Condition of environmental factor Note PubMed ID APOA2 rs5082 C BMI SFA high replicated in both sexes in three populations 19901143 APOE rs429358, rs7412 E2 HDL-C physical activity active in Spanish males 11474482           high intesity in Swiss males 11788473 CETP * rs708272 T HDL-C alcohol 15-30g/day in American males 18063597           any amount in Chinese males 18835593 CETP rs1532624 NR HDL-C physical activity NR reported in three populations 20066028 LIPC rs1800588 C HDL-C total fat less than 30% total energy American 12403660           less than 30% total energy Indian in Singapore 14608050           less than 33.2% total energy in African American females, but not in African American men or in American Whites 17157861   rs1800588 T triglycerides total fat greater than 30% of total energy 3 populations of Singapore: Malay, Indian, Chinese 14608050     T triglyceride:HDL-C ratio total fat greater than 22% 3 populations of Singapore: Malay, Indian, Chinese 14608050 PLIN1 rs1052700 T insulin resistance (HOMA-IR) SFA:CHO ratio greater than 0.19 2 populations of Singapore females: Malay, Chinese 16732014 PLIN1 rs894160 A insulin resistance (HOMA-IR) SFA:CHO ratio greater than 0.19 3 populations of Singapore females: Malay, Indian, Chinese 16732014 PPARG rs1801282 G insulin, fasting PUFA:SFA ratio low UK population, both sexes 14681835     C     greater than 0.66 UK population, both sexes 11246892     C BMI total fat high found in both sexes from Quebec, Canada 12630956     C       found in American females 14506127 SLC2A2 rs5400 NR cholesterol, total physical activity NR reported in two populations 20066028 SLC2A2 rs5400 NR cholesterol, total diet NR reported in two populations 20066028 *this result was not observed in two Spanish studies [20398902, 20581105] NR = not reported

Table 5: Gene-environment interactions replicated in other populations.