Table 1

Overall model characteristic	Diffuse proliferative glomerulonephritis					Proliferative and interstitial disease	Sclerotic glomerulo-nephritis
Model category	Spontaneous	Spontaneous	Induced	Spontaneous		Spontaneous	Spontaneous	Induced
Model name	NZB/W F1 hybrid and NZM2328	SNF1	Pristane induced nephritis	BXSB.Yaa	NZW/BXSB	MRL/lpr	NZM2410	Nephrotoxic nephritis
Antibodies	• Anti-dsDNA	• Anti-dsDNA	• Anti-dsDNA • Anti-chromatin • Anti-Sm/RNP • Anti-ribosomal P	• Anti-RNA • Anti-phospholipid	• Anti-Sm/RNP • Anti-phospholipid	• Anti-dsDNA • Anti-ANA • Anti-Sm • Anti-ssDNA • Anti-RNA • Rheumatoid factor	• Anti-dsDNA • Anti-nucleosome
Renal and non-renal phenotype	• Glomerular enlargement + hypercellularity • T-cell, B-cell, dendritic cell accumulation in perivascular +periglomerular aggregates • Extensive tubulo-interstitial macrophage infiltration	• Glomerular hypercellularity • Thickening of capillary loops + basement membrane • Mesangial thickening • Perivascular infiltrates of lymphoid cells • Fibrosis	• Mesangial and subendothelial deposits	• Monocytosis • Lymphoid hyperplasia • Circulating immune complexes	• Large peri-vascular lymphoid infiltrates • Scattered interstitial T cells • Interstitial and peri-glomerular sheets of macrophages • Glomerular dendritic cell accumulation	• Endothelial and mesangial cell proliferation • Crescents • Mononuclear cell infiltrates - accumulate even when immune complexes are absent • Renal vasculitis	• Early podocyte loss • Interstitial macrophage accumulation • Little lymphocytic or dendritic cell infiltration	• Acute neutrophil and inflammatory Gr1^hi macrophage and T-cell infiltration
Other				• 2 active copies of TLR7 expressed in males		• gIFN response • Deficient in Fas	• IL-4 response • IgG1 + IgE anti-chromatin Abs
References	• Schiffer et al, 2008 [29] •Kalled et al, 1998 [47] • Jacob et al, 2003 [48]	• Kalled et al, 1998 [47]	• Reeves et al, 2009 [18]	• Atif et al, 2006 [49] • Kimura et al, 2011[50]	• Kahn et al, 2008 [51]	• Singh et al, 2003 [52] • Schwarting et al, 1998 [53] • Menke et al, 2009 [54] • Chan et al, 1999 [55]	• Singh et al, 2003 [52]	• Fu et al, 2007 [19] • Timoshanko et al, 2005 [56]

Table 1: Commonly used murine LN models and characteristics.