Overall model characteristic |
Diffuse proliferative glomerulonephritis |
Proliferative and interstitial disease |
Sclerotic glomerulo-nephritis |
|
Model category |
Spontaneous |
Spontaneous |
Induced |
Spontaneous |
Spontaneous |
Spontaneous |
Induced |
Model name |
NZB/W F1 hybrid and NZM2328 |
SNF1 |
Pristane induced nephritis |
BXSB.Yaa |
NZW/BXSB |
MRL/lpr |
NZM2410 |
Nephrotoxic nephritis |
Antibodies |
• Anti-dsDNA |
• Anti-dsDNA |
• Anti-dsDNA
• Anti-chromatin
• Anti-Sm/RNP
• Anti-ribosomal P |
• Anti-RNA
• Anti-phospholipid |
• Anti-Sm/RNP
• Anti-phospholipid |
• Anti-dsDNA
• Anti-ANA
• Anti-Sm
• Anti-ssDNA
• Anti-RNA
• Rheumatoid factor |
• Anti-dsDNA
• Anti-nucleosome |
|
Renal and non-renal phenotype |
• Glomerular enlargement + hypercellularity
• T-cell, B-cell, dendritic cell accumulation in perivascular +periglomerular aggregates
• Extensive tubulo-interstitial macrophage infiltration |
• Glomerular hypercellularity
• Thickening of capillary loops + basement membrane
• Mesangial thickening
• Perivascular infiltrates of lymphoid cells
• Fibrosis |
• Mesangial and subendothelial deposits |
• Monocytosis
• Lymphoid hyperplasia
• Circulating immune complexes |
• Large peri-vascular lymphoid infiltrates
• Scattered interstitial T cells
• Interstitial and peri-glomerular sheets of macrophages
• Glomerular dendritic cell accumulation |
• Endothelial and mesangial cell proliferation
• Crescents
• Mononuclear cell infiltrates - accumulate even when immune complexes are absent
• Renal vasculitis |
• Early podocyte loss
• Interstitial macrophage accumulation
• Little lymphocytic or dendritic cell infiltration |
• Acute neutrophil and inflammatory Gr1hi macrophage and T-cell infiltration |
Other |
|
|
|
• 2 active copies of TLR7 expressed in males |
• gIFN response
• Deficient in Fas |
• IL-4 response
• IgG1 + IgE anti-chromatin Abs |
|
References |
• Schiffer et al, 2008 [29]
•Kalled et al, 1998 [47]
• Jacob et al, 2003 [48] |
• Kalled et al, 1998 [47] |
• Reeves et al, 2009 [18] |
• Atif et al, 2006 [49]
• Kimura et al, 2011[50] |
• Kahn et al, 2008 [51] |
• Singh et al, 2003 [52]
• Schwarting et al, 1998 [53]
• Menke et al, 2009 [54]
• Chan et al, 1999 [55] |
• Singh et al, 2003 [52] |
• Fu et al, 2007 [19]
• Timoshanko et al, 2005 [56] |