Gene   Methylation status Total P   U U/M M IFN-γ Control n (%) 0 (0%) 61 (63.54%) 35 (36.46%) 96 0.02* ESRD n (%) 7(7.3%) 59 (61.5%) 30 (31.2%) 96 SOCS1 Control n (%) 96 (100%) 0 (0%) 0 (0%) 96 0.014* ESRD n (%) 89 (92.7%) 5 (5.2%) 2 (2.1%) 96 SOCS3 Control n (%) 96 (100%) 0 (0%) 0 (0%) 96   ESRD n (%) 96 (100%) 0 (0%) 0 (0%) 96   U Total unmethylation (only the unmethylated allele) U/M Partial methylation (both unmethylated and methylated alleles) M Total methylation (only the methylated allele) The P-value represents Fisher’s exact test results of ESRD patients compared with control group. *Statistically significant at P<0.05.

Table 3: IFN-γ , SOCS1 and SOCS3 promoter methylation in peripheral blood of ESRD patients and controls.