Figure 1: 17 miRNAs showed upregulated and 16 miRNAs were downregulated as listed among which miR-22 demonstrated significant downregulation by 4.8 fold under the treatment of 1 in 40 diluted SFI for 1 hour; miR-107 was significantly upregulated by 6.8 fold and 5.3 fold in the treatment of 1 in 40 diluted SFI for 1 hour and 1 in 20 diluted SFI for 4 hours respectively. Further, miR-200a was also significantly upregulated by 9.6 and 17.2 fold in the treatment with 1 in 20 diluted SFI for 1 hour and 4 hours respectively. Adding the computational evidence of miR-22, miR-107 and miR-200a in association with gene CD80, these three miRNAs were suggested to be involved in the costimulatory regulation on the expression of CD80 over the THP-1 cells and probably the MDDCs treated with SFI through the activation on the TLR-4 receptor.