Protein family Theseus RMSD UniTS RMSD Isocitrate Dehydrogenase 15.23 Å 7.00 Å Pectate Lyase 11.85 Å 6.19 Å Polygalacturonase 1.99 Å 1.57 Å Hemopexin Repeats 3.22 Å 1.74 Å

Table 2: Original RMSD reported by Theseus compared to the UniTS RMSD calculated from the proteins superimposed by Theseus for each protein family.