Protein family Mean chain lengtha DALI res matchesb UniTS res matchesb DALI RMSD IDHc 422 299 (71%) 362 (86%) 2.57 Å Pectate Lyase 375.5 261 (70%) 307 (82%) 1.59 Å Polygalacturonase 342 325 (95%) 331 (97%) 1.13 Å HPX Repd 87.5 70 (80%) 70 (80%) 1.53 Å aMean number of amino acids comprising the two polypeptide chains representing each protein family. bNumber of amino acid residue matches. Parentheses contain the percentage of matched residues utilized out of the total (mean) number of amino acids. Due to length differences between proteins, it is not possible to reach 100% residue matches. cIsocitrate Dehydrogenase. dHemopexin Repeats.

Table 3: Original RMSD reported by Theseus compared to the UniTS RMSD calculated from the proteins superimposed by Theseus for each protein family.