Protein family UniTS Alignment Score Chimera Alignment Score Isocitrate Dehydrogenase -126.7 -437.9 Pectate Lyase 58.0 -108.8 Polygalacturonase 677.2 643.3 Hemopexin Repeats 14.6 16.0

Table 4a: Comparison of the UniTS and Chimera alignment scores utilizing a gap opening penalty of -10.