Protein family UniTS Alignment Score Chimera Alignment Score Isocitrate Dehydrogenase 58.3 -192.9 Pectate Lyase 203.0 71.2 Polygalacturonase 742.2 713.3 Hemopexin Repeats 64.6 56.0

Table 4b: Comparison of the UniTS and Chimera alignment scores utilizing a gap opening penalty of -5.