**Figure 2: Computations of f**_{1} and f_{2}. (A) N sequences and K structures are extracted from the Swiss-Prot and the PDB, respectively. After all the sequences are aligned, and are computed by (B) and (C), respectively. (B) After a phylogenetic tree is written from sequences, is computed. (C) In structure k, ^{k}_{i}
R and ^{k}*Q* denote coordinates of an amino acid residue and coordinates of ions or molecules, respectively. After proximity of* *^{k}_{i}
R and ^{k}*Q* is measured as and computed on K structures, is computed. |