Figure 2: Computations of f1 and f2. (A) N sequences and K structures are extracted from the Swiss-Prot and the PDB, respectively. After all the sequences are aligned, and are computed by (B) and (C), respectively. (B) After a phylogenetic tree is written from sequences, is computed. (C) In structure k, ki R and kQ denote coordinates of an amino acid residue and coordinates of ions or molecules, respectively. After proximity of ki R and kQ is measured as and computed on K structures, is computed.