Figure 1: Including additional clusters based on sequencealignments. A physical cluster of 8 close residues (residues 1-4 and10-13 identified in blue in the table headings) is shown within thedashed circle at the top, with the central one in red. Sequencealignments show variations at the positions shown in highlights. Wewill use these additional sequences from the reliable multiplesequence alignments to include additional clusters with thesespecific sequence changes. The changed sequences in the additionalclusters will significantly enhance the present studies by providing alarge increase in the number of clusters of interacting residues thatavailable for this project, far beyond the number taken directly fromexperimental structures. [modified from [4]]