KEGG orthology (KO) Protein name Major pathways in human diseases Function in pathway
K04077 groEL Tuberculosis chaperonin GroEL
K04077 K03596 groEL lepA Legionellosis chaperonin GroEL GTP-binding protein LepA
K04077 groEL Type I diabetes mellitus chaperonin GroEL
K01679 E4.2.1.2B Renal cell carcinoma fumarate hydratase, class II [EC: 4.2.1.2]
K01679 E4.2.1.2B Pathways in cancer fumarate hydratase, class II [EC: 4.2.1.2]
K00121 frmA Chemical carcinogenesis S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC: 1.1.1.284 1.1.1.1]
K00370 K07704 K11625 narG lytS YdfJ   Two component systems nitrate reductase alpha subunit [EC: 1.7.99.4] LytT family, sensor histidine kinase LytS [EC: 2.7.13.3] membrane protein YdfJ
K00558 DNMT1 MicroRNAs in Cancer DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
Table 4: Major CNS genes involved in the metabolic pathways related to human diseases.