| Bacterial Proteins |
Bacterial non - self antigens |
Homologous Human proteins |
Functions in spermatogenesis / male fertility |
| Laminin binding protein |
SVVTSFYP |
HAS3 |
Enhances tumor growth in prostate cancer cell line, cancer metastasis, tumor growth and progression |
| |
GHLDPKH |
Izumo sperm - egg fusion 1 |
Ig superfamily Izumo required to fuse egg with the sperm; helps in fertilization |
| |
SKTFVTQHT |
SA - 36 |
Isomerase(GPI) / Neuroleukin mRNA sperm agglutination and immobilization |
|
Hyaluronate lyase |
YFRKTLVNPF |
SPATA17 |
spermatocyte apoptosis - related gene involved in human spermatogenesis, especially in meiosis |
| |
NSDQSHYS |
TEX15 |
Chromosomal synapsis and meiotic recombination in spermatocytes |
| |
ILNDKI |
Rosbin1 - like |
regulation in haploid germ cells |
| This table depicts the non - self peptides showing resemblance with Streptococcal peptides. Three non - self peptides with amino acid sequence SVVTSFYP, SKTFVTQHT and GHLDPKH represent human proteins namely Hyaluronan synthase3 (HAS3), Sperm antigen 36 (SA - 36) and Izumo sperm - egg fusion 1(SA) were obtained from Laminin binding protein. Three non - self peptides YFRKTLVNPF, NSDQSHYS and ILNDKI representing human Spermatogenesis associated protein 17(SPATA17), Testis expressed 15 (TEX15) protein and Round spermatid basic protein 1 - like (Rosbin1 - like) were obtained from Hyaluronate lyase protein, respectively. Each of these self - peptides serves to play a major role in spermatogenesis and male fertility function. These non - self peptides of fertilization importance should be discarded from the immunocontraception / vaccine cocktail to restore the fertilization capacity. |
