Overall model characteristic Diffuse proliferative glomerulonephritis Proliferative and interstitial disease Sclerotic glomerulonephritis   Model category Spontaneous Spontaneous Induced Spontaneous Spontaneous Spontaneous Induced Model name NZB/W F1 hybrid and NZM2328 SNF1 Pristane induced nephritis BXSB.Yaa NZW/BXSB MRL/lpr NZM2410 Nephrotoxic nephritis Antibodies • Anti-dsDNA • Anti-dsDNA • Anti-dsDNA • Anti-chromatin • Anti-Sm/RNP • Anti-ribosomal P • Anti-RNA • Antiphospholipid • Anti-Sm/RNP • Antiphospholipid • Anti-dsDNA • Anti-ANA • Anti-Sm • Anti-ssDNA • Anti-RNA • Rheumatoid factor • Anti-dsDNA • Antinucleosome   Renal and nonrenal phenotype • Glomerular enlargement + hypercellularity • T-cell, B-cell, dendritic cell accumulation in perivascular +periglomerular aggregates • Extensive tubulo-interstitial macrophage infiltration • Glomerular hypercellularity • Thickening of capillary loops + basement membrane • Mesangial> thickening • Perivascular infiltrates of lymphoid cells • Fibrosis • Mesangial and subendothelial deposits • Monocytosis • Lymphoid hyperplasia • Circulating immune complexes • Large perivascular lymphoid infiltrates • Scattered interstitial T cells • Interstitial and peri-glomerular sheets of macrophages • Glomerular dendritic cell accumulation • Endothelial and mesangial cell proliferation • Crescents • Mononuclear cell infiltrates - accumulate even when immune complexes are absent • Renal vasculitis • Early podocyte loss • Interstitial macrophage accumulation • Little lymphocytic or dendritic cell infiltration • Acute neutrophil and inflammatory Gr1hi macrophage and T-cell infiltration Other       2 active copies of TLR7 expressed in males • γIFN response • Deficient in Fas • IL-4 response • IgG1 + IgE anti-chromatin Abs   References • Schiffer et al, 2008 [29] • Kalled et al, 1998 [47] • Jacob et al, 2003 [48] • Kalled et al, 1998 [47] • Reeves et al, 2009 [18] • Atif et al, 2006 [49] • Kimura et al, 2011[50] • Kahn et al, 2008 [51] • Singh et al, 2003 [52] • Schwarting et al, 1998 [53] • Menke et al, 2009 [54] • Chan et al, 1999 [55] • Singh et al, 2003 [52] • Fu et al, 2007 [19] • Timoshanko et al, 2005 [56]

Table 1: Commonly used murine LN models and characteristics.