Position D.radioduransDXS P. vivaxdomain swapped DXS E.coliDXS E.coliTK 1 54:SER 401:ALA 52:SER 119:PRO 2 80:VAL 469:ALA 78:VAL XXX:XXXa 3 82:HIS 471:HIS 80:HIS 121:VAL 4 83:GLN 472:SER 81:GLN 121:VAL 5 109:PHE 516:PRO 107:PHE 9:ASN 6 123:GLY 530:ARG 121:GLY XXX:XXXa 7 124:HIS 531:GLY 122:HIS XXX:XXXa 8 125:ALA 532:GLY 123:SER XXX:XXXa 9 153:GLY 558:GLY 151:GLY 33:ILE 10 154:ASP 559:ASP 152:ASP 32:LEU 11 155:GLY 560:GLY 153:GLY 54:ILE 12 156:SER 561:GLY 154:ALA 50:SER 13 157:LEU 562:LEU 155:ILE 49:SER 14 181:ASN 586:ASN 179:ASN 35:TYR 15 183:ASN 588:ASN 181:ASN 31:LEU 16 185:MET 591:VAL 182:GLU 29:ALA 17 186:SER 592:SER XXX:XXXa 55:SER 18 187:ILE 593:LEU XXX:XXXa 55:SER 19 188:SER 594:PRO XXX:XXXa 56:GLY 20 289:LYS 681:LYS 284:LYS 27:ALA 21 347:PRO 778:PRO 344:PRO XXX:XXXa 22 348:ALA 779:ALA 345:ALA 56:GLY 23 349:MET 780:MET 346:MSE XXX:XXXa 24 371:ILE 802:ILE 368:ILE 53:ALA 25 373:GLU 804:GLU 370:GLU XXX:XXXa 26 395:TYR 827:TYR 392:TYR XXX:XXXa 27 398:PHE 830:PHE 395:PHE XXX:XXXa 28 401:ARG 833:ARG 398:ARG XXX:XXXa 29 434:HIS 866:HIS 431:HIS XXX:XXXa

Table 5: Comparison of residues in the active-sites of DXS homology models and templates.