Figure 1: Assessment of neurological deficit scores and histochemistry confirm that NAE 16:0 protects against ischemic brain damage following MCAO I/R. (A) MCAO-mediated I/R caused moderate to severe neurological deficits, as measured with the standardized neurological deficit score, and treatment with NAE 16:0 reduced neurological deficits significantly (phenotype: none to mild). (B) The size of the ipsilateral ischemic lesion volume (infarct volume) was significantly reduced by NAE 16:0 treatment. Data are shown as mean SE. aP < 0.05, compared with I/R vehicle-treated group as determined using one-way ANOVA with Newman Keuls multiple comparison post-hoc test.